hrp0089wg5.3 | ESPE Paediatric and Adolescent Gynaecology Working Group (PAG) | ESPE2018

Influence of Adiposity as a Determinant of the Age at Pubjeanertal Onset

Biro Frank

Multiple studies have examined the relationship between BMI and timing of the onset of puberty. The more salient measure of this relationship may be adiposity, which can be represented by fat mass, BMI z-score, or waist-to-height ratio. The relationship of greater BMI or adiposity to earlier pubertal onset in girls is generally consistent, and several mechanisms have been proposed. These potential mechanisms include impact of adiposity on leptin concentrations, altere...