hrp0095p1-543 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Klotho response to treatment with GnRH agonist in children with central precocious puberty

Seo Yoon Jong , Bit Gyeol Kim , Tae Hwang Il

Background: Klotho is an anti-aging protein acting as a circulating hormone. Major physiologic activities attributed to klotho include regulation of phosphate and calcium homeostasis, aging, adipogenesis, and glucose metabolism. Pubertal children had higher klotho than prepubertal. Insulin like growth factor-1 (IGF-1) directly promotes klotho shedding. Klotho levels significantly correlated with IGF-1 standard deviation scores (SDS).<str...