hrp0098fc14.4 | Fetal and Neonatal Endocrinology | ESPE2024

Efficacy and Safety across Subgroups in Children with Congenital Hyperinsulinism Treated with Dasiglucagon

Banerjee Indraneel , S. Thornton Paul , Birch Sune , Boge Eva , Ivkovic Jelena , Gondolf Theis , D Leon Diva

Background: Congenital hyperinsulinism (CHI) is a rare disease affecting neonates, infants, and children caused by dysregulated insulin secretion resulting in severe recurrent hypoglycemia. Early treatment is necessary to limit the risk of neurologic and developmental sequelae. Dasiglucagon is a glucagon analog (stable liquid formulation) suitable for continuous subcutaneous infusion shown to raise blood glucose in a dose-dependent manner. Result...