hrp0098p1-246 | Fetal and Multisystem Endocrinology | ESPE2024

Rarity of congenital adrenal hyperplasia in children born verypreterm: Possible mechanism and implication for newborn screening

Ladjouze Asmahane , Ouarezki Yasmine , Djermane Adel , Kherra Sakina , Bensalah Meriem , Mohammedi Kahina , Douiri Dalila , Boutaghene Nourredine , Bouzerar Zair , Van Vliet Guy

Screening for congenital adrenal hyperplasia through the measurement of 17-hydroxyprogesterone on the neonatal blood spot, aims to: prevent neonatal deaths; allow earlier identification and thereby decrease the severity of the initial salt-wasting episode; and to shorten the time during which a severely virilized genetic female newborn may be assigned the male sex. It is now practiced in most high-income countries, although the positive predictive value of the test is very low...