hrp0097fc14.3 | Late Breaking | ESPE2023
Cassorla MD Fernando
, Román MD Rossana
, Linn Johnson PhD Michael
, Avila RN Alejandra
, Iñiguez MD German
, Baier MD Ingrid
, Said RN Daniela
, Bruchey PhD Aleksandra
, Smith MS Christopher
, L. Brinks PhD Erik
, C. McKew PhD John
, B. Karpf MD David
, O. Thorner MD Michael
, DSc MBBS
An oral GH secretagogue (GHS), LUM-201, stimulates GHSR-1a receptor to enhance endogenous GH pulsatile release. In moderate iPGHD, pulses of GH are found but at reduced levels, resulting in decreased IGF-1 and poor growth. The impact of LUM-201 on GH profiles during treatment of such children has not been reported.Objective: To characterize GH profiles, defined by deconvolution analysis, based on GH concentration in a time series and its...