hrp0084p3-680 | Bone | ESPE2015

Efficacy and Safety of Oral Alendronate Treatment in Children and Adolescents with Osteoporosis

Buyukgebiz Atilla , Bober Ece , Abaci Ayhan

Background: Osteoporosis is very rare in childhood and main reasons are growth retardation, immobilisation, calcium and vitamin D deficiency, long term steroid therapy. There is no concensus about the treatment of children and adolescents with osteoporosis. Biphosphonates have been important in the treatment of osteoporosis.Objective and hypotheses: To evaluate the efficacy and safety of oral alendronate on bone mineral density (BMD) in children and adol...

hrp0082p3-d1-924 | Puberty and Neuroendocrinology | ESPE2014

Leptin Levels in Boys with Pubertal Gynecomastia

Buyukgebiz Atilla , Dundar Bumin , Dundar Nihal , Bober Ece

Background: It has been reported that there is a relationship between circulating leptin and sex steroid hormones and leptin is able to stimulate estrogen secretion by increasing aromatase activity in adipose stromal cells and breast tissue. Leptin receptors have been also shown in mammary epitheleal cells and it has been suggested that leptin is involved in the control of the proliferation of both normal and malignant breast cells.Objective and hypothes...