hrp0084p3-624 | Adrenals | ESPE2015

Clinical and Genotypic Characterization of Simple Virilising Forms of Congenital Adrenal Hyperplasia

Cardoso Rita , Pacheco Susana , Caetano Joana Serra , Dinis Isabel , Mirante Alice

Background: Congenital adrenal hyperplasia (CAH) is a recessive disease in 90% caused by 21-hidroxilase deficiency. The clinical manifestations are related with the severity of enzyme deficiency and are classified in classical and non classical forms. The classical form is the most severe with genital ambiguity in female newborns and universal virilisation. In 75% there is also aldosterone deficiency with salt wasting.Objective and hypotheses: To describ...

hrp0084p3-1203 | Thyroid | ESPE2015

Newborns of Mothers with Graves’ Disease: Survey of 14 Years

Cardoso Rita , Jeronimo Monica , Caetano Joana Serra , Dinis Isabel , Mirante Alice

Background: GravesÂ’ disease (GD) is the most common cause of hyperthyroidism in fertile woman and can cause fetal and neonatal hyper or hypothyroidism. It is associated with transplacental transfer of maternal thyrotropin receptor antibodies (TRAb).Objective and hypotheses: The main objective of this study was to characterize the neonates born to women with GD followed in a pediatric endocrinology reference unit.Method: A retr...

hrp0089p3-p194 | GH & IGFs P3 | ESPE2018

Growth Hormone Treatment: Does Timing Matter?

Marques Bernardo , Gomes Sonia Madeira , Caetano Joana Serra , Cardoso Rita , Dinis Isabel , Mirante Alice , Fitas Ana Laura , Diamantino Catarina , Limbert Catarina , Pina Rosa , Lopes Lurdes

Introduction: Treatment with recombinant growth hormone (rGH) is safe and has greatly improved the approach of children and adolescents with growth hormone deficiency (GHD) and other growth disorders. Some studies show that most of the height gain associated with GH treatment occurs in prepubertal years. The aim of our study was to evaluate the effect of age at start of the treatment on final height in children with isolated or GHD in a Portuguese cohort.<p class="abstext"...

hrp0086rfc3.7 | Pituitary | ESPE2016

Pituitary Structural Abnormalities in Idiopathic Isolated Growth Hormone Deficiency

Cardoso Luis , Vicente Nuno , Dias Ines , Caetano Joana Serra , Cardoso Rita , Dinis Isabel , Bastos Margarida , Rodrigues Dircea , Carrilho Francisco , Mirante Alice

Background: Isolated growth hormone deficiency is the most common pituitary hormone deficiency, although the majority of cases are idiopathic. The presence of pituitary structural abnormalities may influence growth hormone (GH) deficiency severeness.Objective: Assess the effect of pituitary abnormalities in idiopathic isolated growth hormone deficiency (IIGHD).Methods: We analysed 65 children with IIGHD and pituitary magnetic resso...