hrp0098fc12.2 | Thyroid | ESPE2024

Molecular Characterization of Childhood Thyroid Nodules and Thyroid Cancer with DNA/RNA Next Generation Sequencing and Investigation of Phenotype-Genotype Correlation

Aycan Zehra , Kızılcan Çetin Sirmen , Karadağ Kıvrak Hale , Ceyhan Koray , Şıklar Zeynep , Berberoğlu Merih , Özsu Elif , Suat Fitöz Ömer , Dizbay Sak Serpil

Background: Our study aimed to determine the molecular characterization of thyroid nodules and cancer in childhood and investigate the genotype-phenotype relationship.Methods: The pre-postoperative clinical follow-up features and genetic characteristics of 62 patients were evaluated. Next-generation sequencing (NGS) was used to investigate common variants in thyroid lesions with sufficient tissue in the pathology archive...

hrp0095p1-392 | Thyroid | ESPE2022

Clinical Features, Risk Classifications and Long-Term Follow Up Of Childhood Differentiated Thyroid Cancer(DTC): A Single Reference-Center Experience

Aycan Zehra , Çetin Sirmen Kızılcan , Zeynep Şıklar , Elif Özsu , Fitöz Suat , Ceyhan Koray , Yağmurlu Aydın , Göllü Bahadır Gülnur , Ünal Emel , Taşyıldız Nurdan , Kır Metin , Soydal Çiğdem , Berberoğlu Merih

Background: Thyroid cancers are rare in childhood. ATA guideline (Pediatric section) has been applied in daily practice since 2015. It is very significant to accurately predict the risk in the management of differentiated thyroid cancer(DTC). For this purpose, we shared our single center-20-year-experience about the follow-up features and management of childhood and adolescent thyroid cancer. We aimed to evaluate the dynamic risk stratification (DRS) and the o...