ESPE Abstracts

Early puberty is associated with obesity in young girls and has physical, psychosocial, and reproductive implications. In adults and children, MRI evidence of cellular inflammation in the mediobasal hypothalamus (MBH gliosis) is seen in obesity, and its anatomic location overlaps with key neuronal populations controlling reproduction, fertility, and feeding. We sought to assess whether MRI evidence of MBH gliosis associates with pubertal development in girls and if that differ...