hrp0082s4.3 | Recent Advances in Our Understanding of Hypothyroidism | ESPE2014
Novel Insights into Thyroid Hormone Resistance
Resistance to thyroid hormone mediated by defective TRβ (RTHβ) or TRα(RTHα).Separate genes (THRA, THRB) undergo alternate splicing, generating nuclear receptors (TRα1, TRβ1, TRβ2) with distinct tissue distributions, which mediate thyroid hormone action; the function of a non-hormone binding protein (α 2), derived from the THRA locus, is unknown.RTHβ a dominantl...
ESPE Abstracts
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