hrp0089p3-p399 | Diabetes & Insulin P3 | ESPE2018

Family Investigation and Clinical Phenotype Analysis of Type A Insulin Resistance Syndrome

Chen Yonghua , Chen Hong , Fang Yanlan , Wang Chunlin , Zhu Jianfang , Liang Li

Objective To study a large Chinese family with Type A Insulin Resistance Syndrome (TAIRS) and the membersÂ’ clinical phenotypes. Explore their genotype-phenotype relationship between environmental factors and hereditary features. Methods 19 members of the family were investigated for their past history, dietary habits and living habits. PCR and Sanger sequencing were applied to detect mutations of the INSR gene among 6 core members from the Pedigree. Besides, fasting blood...