ESPE Abstracts

Background: Dysregulation of metabolic regulatory hormones, particularly reduction of growth hormone (GH) and increase in insulin, often occurs during the progress of obesity. Such GH:insulin balance has recently been proposed critically important in affecting metabolism profiles. Time-restricted feeding (TRF) is an effective strategy against obesity and was tested in this study. Compared to wild type mice, LEAP-2 KO mice is prone to obesity induced by high fa...