hrp0086p1-p608 | Growth P1 | ESPE2016

Pubertal Height Gain in Females with Isolated Growth Hormone Deficiency Treated with rhGH Alone or in Combination with GnRHan

Voutetakis Antonis , Chiotis Dimitris , Gryparis Alexandros , Kanaka-Gantenbein Christina , Dacou-Voutetakis Catherine

Background: A significant component of total linear growth is height gain achieved after the initiation of puberty. Children with Isolated GH Deficiency (IGHD) frequently come for evaluation around the peripubertal stage. Therefore, increasing pubertal height gain in IGHD children entering puberty with a relatively low height is important. Researchers have tried to assess effectiveness of treatment in such patients based on various key measurements and a variety of end-points....

hrp0084p2-521 | Puberty | ESPE2015

A Novel Entity Characterised by GH Deficiency and Central Precocious Puberty in Two Siblings and their Father, in the Absence of Central Nervous System Defect

Voutetakis Antonis , Chiotis Dimitris , Dracopoulou-Vabouli Maria , Magiakou Alexandra-Maria , Chrousos Georgia , Chrousos George , Dacou-Voutetakis Catherine

Background: The association of GH deficiency (GHD) with central precocious puberty (CPP) has been reported in individuals with central nervous system (CNS) abnormalities, congenital or acquired. Co-existence of GHD and CPP has been rarely reported, always as an isolated, sporadic disorder.Objective and hypotheses: To present the familial occurrence of combined GHD and CPP.Method: GH was measured post L DOPA, glucagon and GHRH and g...