hrp0086p1-p920 | Thyroid P1 | ESPE2016

Lowering of the TSH cut-off Limit Substantially Alters Universally Accepted Key Features of Congenital Hypothyroidism. Reconsideration of the Use of FT4 levels for Diagnosis and Treatment

Iliadi Alexandra , Gika Anna , Platis Dimitris , Giogli Vasiliki , Chouliaras Giorgos , Kosteria Ioanna , Kazakou Paraskevi , Apostolaki Despoina , Chrousos George , Girginoudis Panagiotis , Kanaka-Gantenbein Christina , Voutetakis Antonis

Background: The term Congenital Hypothyroidism (CH) describes children with subnormal thyroid hormone levels present at birth. According to literature, CH has an incidence of ~1:1500–1:3000 births with a clear predominance of females (female:male ratio 2:1) and is mainly caused by thyroid dysgenesis (80%). Low FT4 levels have been used as important criteria for CH diagnosis and treatment initiation. The Greek neonatal CH screening program has followed the TSH cut-off lowe...