hrp0084p2-295 | Diabetes | ESPE2015

Sirolimus Therapy in Infants with Congenital Hyperinsulinism after Near Total Pancreatectomy

Choi keun Hee , Chung Hye Rim

Background: Congenital hyperinsulinism is the most common cause of persistent hypoglycaemia in neonates and children. It is important to minimize recurrence of episodes of hypoglycaemia. In some cases, Hypoglycemia was not controlled even after near total pancreatectomy.Objective and hypotheses: To study the glycemic response of sirolimus in patients with hyperinsulinemic hypoglycaemia that was not responsive to octreotide and calcium channel blocker aft...

hrp0084p2-574 | Thyroid | ESPE2015

Years Follow-Up of Children with Abnormal Newborn Screening Results for Congenital Hypothyroidism: Who Needs Treatment and Who Needs Permanent Treatment?

Kang Min Jae , Shim Young Suk , Oh Yeon Joung , Chung Hye Rim , Yang Seung , Hwang Il Tae

Background: As newborn screening test (NST) became popular, the incidence of congenital hypothyroidism (CH) was raised. But not all CH children require lifelong levothyroxine (LT4) replacement therapy.Objective and hypotheses: We aimed to analyse predicting factors suggesting transient CH (TCH) compared to permanent CH (PCH) or transient thyroid function test (TFT) abnormality who had a positive screening results in our centers for the past de...

hrp0084p3-756 | Diabetes | ESPE2015

Factors Related to Progression to Macroalbuminuria in Type 1 Diabetic Children with Microalbuminuria

Choi Keun Hee , Kim Hwa Young , Jung Hae Woon , Lee Gyung Min , Jung Kyung A , Kim So Youn , Lee Young Ah , Chung Hye Rim , Shin Choong Ho , Yang Sei Won

Background: Microalbuminuria is usually the earliest sign of diabetic nephropathy. However, it does not always progress to macroalbuminuria,and may regress to normoalbuminuria. Mean HbA1c and HbA1c variability was known to be independent risk factors for microalbuminuria in children with type 1 diabetes.Objective and hypotheses: We hypothesised that both mean and variability of HbA1c could affect the progression to macroalbuminuria in children with type ...