ESPE Abstracts

Introduction: Central precocious puberty is characterized by early activation of pituitary-gonadal axis, often associated with high levels of insulin-like growth factor-I (IGF-I), together with accelerated growth and bone maturation, which can ultimately lead to a low adult height (HT). Treatment with GnRH-agonists (GnRHa) can help reducing growth acceleration and rate of bone maturation, though not always restoring prepubertal growth velocity. The causes of d...