hrp0095p1-164 | Pituitary, Neuroendocrinology and Puberty | ESPE2022
d'Aniello Francesco
, Ubertini Graziamaria
, Elisa Amodeo Maria
, Mirra Giulia
, Criscuolo Sabrina
, Mucciolo Mafalda
, Fintini Danilo
, Cappa Marco
Introduction: We report a series of three siblings, two girls and one boy, diagnosed with Central Precocious Puberty (CPP) respectively at the age of 5.66, 6.67 and 8.5 years, carrying a mutation in the gene encoding the makorin RING finger protein 3 (MKRN3), usually responsible for the development of familial CPP.Methods: We diagnosed CPP in all the patients by performing a GnRH test. We also dosed basal levels of LH, F...