hrp0095p1-38 | Diabetes and Insulin | ESPE2022
, Hopkins Jasmin
, Flanagan Sarah
, Ashotyan Azatuhi
, Navasardyan Lusine
Introduction: Congenital hyperinsulinism (CHI) is a disorder of pancreatic beta-cells characterized by inappropriate secretion of insulin leading to hyperinsulinemic hypoglycemia. Insulin secretion is a complex, genetically regulated process. Mutations in several genes known to regulate insulin secretion result in CHI. Recently, non-coding mutations in HK1, which cause the aberrant expression of hexokinase 1 (HK1) in beta cells, have been reported as a novel c...