hrp0086rfc7.7 | Gonads & DSD | ESPE2016

Clinical Decision-Making in Disorders of Sex Development (DSD): Physician Recommendations Pre- and Post-Consensus Statement

Sandberg David E. , Kogan Barry , Gardner Melissa

Background: Despite advances in genetic diagnosis and surgical technique, and guidance from the Consensus Statement on Intersex Disorders, aspects of clinical management in disorders/differences of sex development (DSD) remain unsettled. Actively debated decision points include gender of rearing in specific syndromes, genital surgery prior to the patient developing the capacity to provide assent, and uncertainty over how and when to best educate young patients about diagnostic...

hrp0086p2-p424 | Gonads & DSD P2 | ESPE2016

Follow-up to Adulthood of Two 46,XY Siblings with 5-alpha Reductase Deficiency and Different Sex of Rearing

Chiniara Lyne , Sandberg David , Van Vliet Guy

Background: 46,XY patients with 5α-reductase deficiency (5-ARD), reared from birth as girls, are reported to self-reassign as boys subsequent to a masculinizing puberty; whether this holds true in cases of early orchidectomy is less well documented.Objective and hypotheses: Prepubertal orchidectomy reduces the likelihood of gender self-reassignment.Method: Presentation, management and outcome of two siblings with 5-ARD with na...

hrp0086p1-p609 | Growth P1 | ESPE2016

Cognitive Abilities and Academic Achievement Among Youths with Short Stature Receiving Growth Hormone Therapy

Yeguez Carlos , Gardner Melissa , Sandberg David

Background: Reports suggest that youths with short stature (SS) exhibit academic under-achievement relative to cognitive aptitude and GH treatment diminishes the difference. However, interpretation of this achievement-aptitude discrepancy is confounded by the use of achievement and intelligence tests normed in different samples.Objective and hypotheses: To assess whether reports of academic underachievement in SS samples are partially attributable to cho...

hrp0084s3.2 | Disorders of sex development: An update | ESPE2015

Decision Making in DSD: Development of a Decision Support Tool

Sandberg David , Callens Nina , Siminoff Laura

Background: Disorders/differences of sex development (DSD) differ from other rare conditions which are often accompanied by significant morbidity and mortality. With limited exceptions, DSD are not life-threatening and do not predict a given level of physical health or health-related quality of life across the lifespan. The birth of a child with DSD is anxiety-provoking. Stressors include weathering drawn-out diagnostic testing, difficulty absorbing complex medical information...

hrp0092p1-125 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

A Health-Related Quality of Life Tool for Parents of Young Children With Disorders of Sex Development

Ali Salma , Macqueen Zoe , Gardner Melissa , Sandberg David , Kyriakou Andreas , Mason Avril , Shaikh M. Guftar , Wong Sze Choong , Ahmed S. Faisal

Background: Disorders of sex development (DSD) may be associated with adverse psychosocial and psychosexual outcomes in adults. However, there is a paucity of information on health-related quality of life outcomes in parents and young children with DSD.Objective: To evaluate the use of parent-reported outcome (PRO) questionnaires that can be routinely used in the outpatient setting to assess the impact of DSD on parents ...