hrp0084p2-173 | Adrenals | ESPE2015

Normal Ranges of Basal and Glucagon-Stimulated Free Cortisol in Children

Davidov Anita Schachter , Eyal Ori , Anat Anat Becker , Oren Asaf , Stern Naftali , Limor Rona , Weintrob Naomi

Background: Standard assays for serum cortisol measurements determine total cortisol (TC) concentrations but not the unbound biologically active serum free cortisol (sFC). Measurement of TC would be greatly influenced by alteration in cortisol-binding globulin (CBG) concentrations. It is, therefore, important to determine sFC levels when CBG levels are either decreased or increased.Objective and hypotheses: To determine basal and glucagon-stimulated sFC ...

hrp0084p2-318 | DSD | ESPE2015

When, if Ever, Should the Müllerian Remnants be Removed from Subjects with Mixed Gonadal Dysgenesis Raised as Males?

Segev-Becker Anat , Meisler Sarah , Eyal Ori , Oren Asaf , Davidov Anita Schachter , Weintrob Naomi

Background: Mixed gonadal dysgenesis (MGD) is the second most frequent cause of XY disorders of sex development (DSD). Genotype is either X/XY or XY, while the phenotype ranges from partial to complete gonadal dysgenesis, and from female to male external genitalia. Müllerian remnants are present in these patients because of insufficient or untimely foetal secretion of Müllerian inhibiting factor (MIF).Aim: To assess the therapeutic policy of ph...