hrp0086rfc1.3 | Adrenals | ESPE2016
Lamprokostopoulou Agaristi
, Varela Aimilia
, Katsimpoulas Michalis
, Dimitriou Constantinos
, Athanasiadis Nikos
, Soultou Eleana
, Stefa Alketa
, Mavroides Manolis
, Davos Constantinos H.
, Chrousos George P.
, Kino Tomoshige
, Georgopoulos Spiros
, Charmandari Evangelia
Background: Glucocorticoids regulate a broad spectrum of physiologic functions essential for life and exert their actions through their ubiquitously expressed glucocorticoid receptor (GR). The GR interacts with several molecules, including the non-coding RNA growth arrest-specific 5 (Gas5), which decreases the transcriptional activity of the GR by preventing its binding to DNA, and reduces tissue sensitivity to glucocorticoids.Objective and Hypotheses: T...