hrp0084p3-1008 | Growth | ESPE2015

Presenting Characteristics, Auxological, and Aetiologic Evaluation of 364 Patients with GH Deficiency

Ozbek Mehmet Nuri , Baysal Birsen , Tanriverdi Sibel , Deniz Ahmet , Oncel Kahraman , Ocal Murat , Baran Riza Taner , Demirbilek Huseyin

Background: GH deficiency (GHD), can either be isolated (IGHD) or part of multiple pituitary hormone deficiency (MPHD), is a pituitary hormone disorder that manifests with short stature.Objective and hypotheses: To evaluate the presenting characteristics, auxological and etiologic factors of GHD in a large cohort from a single tertiary paediatric endocrine centre.Methods: Hospital files of patients followed with GHD deficiency at D...

hrp0084p3-1078 | Hypo | ESPE2015

Long Acting Somatostatin Analogues in the Management of Congenital Hyperinsulinism in Cases with Poor Compliance to Conventional Therapy

Demirbilek Huseyin , Oncel Kahraman , Ozbek Mehmet Nuri , Deniz Ahmet , Baysal Birsen , Arya Ved Bhushan , Flanagan Sarah E , Ellard Sian , Hussain Khalid

Background: Congenital hyperinsulinism (CHI), is the most common cause of severe hypoglycaemia in neonates and infants. The cornerstone of medical therapy is diazoxide. Octreotide, a somatostatin analogue, is the second therapeutic option in diazoxide unresponsive cases. However, due to its short half-life and requirement of multiple daily doses, lack of compliance may cause recurring hypoglycaemia and related neurological deficits, particularly for the family with low socioec...