ESPE Abstracts

Introduction: Limited research has focused on the potential connection between thyroid function and attention-deficit/hyperactivity disorder (ADHD), particularly beyond prenatal effects. The few studies addressing children and adolescents have important methodological shortcomings, mainly when seeking to establish causality. To clarify this relationship, a combined epidemiological and genetic approach was adopted to overcome the methodological limitations of e...

The steroid constellation in affective disorders suggests a stress-related pathogenesis or response and may pave the way for novel therapeutic strategies. In adolescents, previous studies have identified hypothalamic-pituitary-adrenal (HPA) axis dysregulation with hypercortisolemia. However, evidence so far is limited to a subset of the steroid spectrum, predominantly focusing on glucocorticoids. In order to gain a more holistic understanding, we analyzed urine metabolites of ...