hrp0097p1-211 | Adrenals and HPA Axis | ESPE2023

Salivary 11-oxygenated 19-carbon steroids in children with congenital adrenal hyperplasia and Addison's disease compared to healthy children

Park Julie , Hawcutt Daniel , Shantsila Alena , Bright Orla , Dliso Silothabo , Lip Gregory , Blair Joanne

Background: 11-oxygenated 19-carbon (11oxC19) steroids, 11ketotestosterone (11KT) and 11βhydroxyandrostenedione(11OHA4) are adrenally derived steroids that rise in congenital adrenal hyperplasia (CAH). Increased 11oxC19 concentrations are associated with markers of poor control of CAH. To date, 11oxC19 concentrations have not been measured in patients with Addison’s disease (AD).Methods: Children with primary ...

hrp0098rfc4.2 | Adrenals and HPA Axis 1 | ESPE2024

Salivary cortisol and cortisone is related to age

McNally Sarah , Park Julie , Shantsila Helen , Dliso Silothabo , Hawcutt Dan , Blair Jo

Background: Cortisol is a hormone critical for good health. Concentrations of cortisol are reported to be increased in people born small for gestational age and obese children. Cortisol excess and deficiency are associated with growth disturbances and changes in blood pressure (BP). Salivary cortisol (SC) and cortisone (SCn) correlate strongly with serum cortisol. In this study we investigated the relationship between SC and SCn, auxological parameters, BP, ag...