ESPE Abstracts

Background and aims: Insight into which determinants associate with bone mineral density (BMD) is needed for targeted therapy in children with a low BMD for chronological age but also for preventive treatment on population level. Currently, studies investigating determinants of BMD in children aged <4 years are scarce. The primary aim of our study was to assess which determinants associate with BMD total body less head (BMDTBLH) at around age 6 m...

Background and aims: Breastfeeding is associated with different adiposity development in infants and a reduced overweight risk. Human milk contains large lipid globules with a native membrane rich in phospholipids, whereas lipid droplets in most conventional infant formulas (IF) are small and protein-coated. Our study aims to evaluate the impact of a Concept IF with large, milk phospholipid-coated lipid droplets, closer to human milk lipid globule characterist...

Background: Being born small for gestational age (SGA) has been associated with a reduction in health-related quality of life (HRQoL) and more problem behaviour. Growth hormone (GH) treatment, which leads to a significant improvement in adult height (AH), improves HRQoL and decreases problem behavior in SGA children. However, such results are very limited in SGA adults who were treated with GH during childhood.Objective:...

Background: Short stature has been associated with a reduction in health-related quality of life (HRQoL) and more problem behavior in children and adults. In adolescents who were treated with growth hormone (GH) because of persistent short stature after being born SGA, an increase in HRQoL and decrease in behavioral problems was seen during or right after cessation of GH-treatment. However, long-term data, to analyze if these positive effects remain many years...

Background and aims: Poly- and perfluoroalkyl substances (PFAS) are non-degradable, man-made-chemicals. PFAS are considered to be ‘Endocrine Disrupting Chemicals’ (EDCs), a group of chemicals which have been reported to interfere with endocrine processes and cause adverse effects on perinatal, neurodevelopmental, metabolic and reproductive outcomes. Especially when exposure occurs during susceptible periods of human development, such as early life....

Background: The French population of the SAGhE study showed an increased morbidity and mortality due to cerebrovascular disease in growth hormone (GH) treated subjects compared to the general population. Cerebrovascular health can be assessed using neuroimaging markers on MRI. One of the markers is white matter hyperintensity (WMH).Objective: To assess cerebrovascular health by scoring WMH on MRI in young adults born sma...

Background: Increased cerebrovascular morbidity and mortality was reported in adults who were treated with growth hormone (GH) during childhood, including those born SGA, compared to the general population. However, previous studies did not have an appropriate control group of untreated SGA adults which was a major limitation.Objective: To assess cerebrovascular abnormalities (aneurysms, previous intracerebral hemorrhage...

Background and Aims: Extreme preterm birth (EPB), <30 weeks gestation, significantly impacts skeletal development due to decreased bone mineralization, with approximately 16-40% of EPBs developing metabolic bone disease of prematurity (MBDP). To investigate if MBDP persists into childhood with the current feeding protocols for EPBs, our objective was to compare bone mineral density (BMD) around (corrected) age 5 years in EPB children versus children born te...