hrp0086p1-p928 | Thyroid P1 | ESPE2016

Preliminary Results: Body Composition of Adolescent Patients with Congenital Hypothyroidism and Correlation with Laboratory Parameters

Doulgeraki Artemis , Petrocheilou Glykeria , Polyzois Georgios , Tsoka Eleni

Background: Thyroid dysfunction may predispose to imbalanced body composition.Objective and hypotheses: The aim of the study is to evaluate bone, muscle and fat mass in teenagers with congenital hypothyroidism and correlate their bone profile with laboratory parameters, in an effort to offer more effective lifestyle counselling.Method: Adolescents diagnosed with congenital hypothyroidism through neonatal screening underwent thoroug...

hrp0092p3-275 | Late Breaking Abstracts | ESPE2019

Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Normal-Weight, Overweight and Obese Adolescent Females

Bacopoulou Flora , Apostolaki Despoina , Mantzou Aimilia , Doulgeraki Artemis , Pałasz Artur , Koniari Eleni , Efthymiou Vasiliki

Background: The Spexin gene is considered the most dysregulated in obese human fat with an almost complete absence of expression in obese human fat in comparison with non-obese fat tissues. Limited data from human and animal studies suggest that the novel peptide spexin may potentially impact food intake, weight regulation and body adiposity.Objective: The aim of this study was to compare serum spexin concentrations betw...

hrp0089p3-p040 | Bone, Growth Plate & Mineral Metabolism P3 | ESPE2018

A Novel p.Gly775Glu Missense COL1A2 Mutation Causes Severe Osteogenesis Imperfecta in a Prepubertal Girl

Kotanidou Eleni P , Doulgeraki Artemis , Costantini Alice , Makitie Outi , Athanasopoulou Helen , Laliotis Nikolaos , Galli-Tsinopoulou Assimina

Background: Osteogenesis imperfecta (OI) due to COL1A1 and COL1A2 mutations is the most common cause of primary osteoporosis.Case presentation: We present a 10-year-old girl with a history of skeletal fragility, starting in the perinatal period. Her parents are not consanguineous and there is no family history of early osteoporosis. To date, she has sustained nineteen low-energy, long bone fractures and she has skeletal deformities (leg length discrepanc...

hrp0086p1-p378 | Gonads & DSD P1 | ESPE2016

Randomized Controlled Study Comparing Vitamin D and Omega 3-Fatty Acids Supplementation in Adolescents with Polycystic Ovary Syndrome

Bacopoulou Flora , Kolias Evangelia , Aravantinos Leon , Mantzou Aimilia , Doulgeraki Artemis , Spanoudi Filio , Deligeoroglou Efthimios , Charmandari Evangelia

Background: Polycystic ovary syndrome (PCOS) is a complex endocrine genetic disorder, which is associated with increased metabolic and cardiovascular morbidity. Vitamin D or omega-3 fatty acids supplementation may alleviate the metabolic and reproductive complications of PCOS.Objective and hypotheses: To compare clinical, psychometric, biochemical, endocrine, bone and sonographic markers in vitamin D sufficient adolescents with PCOS, pre- and post- 6 mon...

hrp0082p1-d3-54 | Bone (1) | ESPE2014

Correlation of Sclerostin Levels with Bone Metabolism Markers and Bone Mineral Density in Children and Adolescents with Type 1 Diabetes Mellitus (T1DM)

Tsentidis Charalampos , Gourgiotis Dimitrios , Kossiva Lydia , Marmarinos Antonios , Papathanasiou Asteroula , Doulgeraki Artemis , Karavanaki Kyriaki

Background: Sclerostin is an inhibitor of the Wnt/b-catenin bone metabolic pathway. Increased sclerostin levels and reduced bone mineral density (BMD) have been documented in adult patients with diabetes mellitus (DM), predominantly in those with T2DM. No relevant data exist on childhood T1DM.Objective and hypotheses: Our aim was to study plasma sclerostin concentration in children and adolescents with T1DM and controls and to correlate sclerostin levels...

hrp0082p1-d3-55 | Bone (1) | ESPE2014

Increased Osteoclast Activity in Children and Adolescents with Type 1 Diabetes Mellitus Indicated by Higher Levels of Osteoprotegerin and s-RANKL may Predispose to Lower Bone Mass

Tsentidis Charalampos , Gourgiotis Dimitrios , Kossiva Lydia , Doulgeraki Artemis , Marmarinos Antonios , Sdogou Triantafillia , Karavanaki Kyriaki

Background: Several bone metabolic pathways seem to be disrupted in patients with type 1 diabetes mellitus (T1DM), leading to reduced bone mass.Objective and hypotheses: Our aim was to study bone metabolism markers in children and adolescents with T1DM and their correlation with bone mineral density (BMD).Method: We evaluated 40 patients (mean±S.D. age 13.04±3.53 years, mean±S.D. T1DM du...

hrp0084p1-25 | Diabetes | ESPE2015

Lower Bone Mineral Density in Type 1 Diabetes Mellitus (T1DM) is Probably Associated with Wnt/β-Catenin Pathway Downregulation Through Increased Dickkopf-1 Levels

Karavanaki Kyriaki , Tsentidis Charalampos , Kossiva Lydia , Marmarinos Antonios , Doulgeraki Artemis , Gourgiotis Dimitrios

Background: Disruption of many bone metabolic pathways and reduced bone mass are associated with diabetes mellitus. Increased fracture risk and elevated Dickkopf-1 and sclerostin levels, which are inhibitors of Wnt/β-catenin pathway, have been found in adult T2DM patients, but no relevant data exist on childhood T1DM.Objective and hypotheses: We aimed at studying plasma Dickkopf-1 and sclerostin concentration in children and adolescents with T1DM an...

hrp0086p2-p148 | Bone & Mineral Metabolism P2 | ESPE2016

A Preliminary Report on Body Composition Profile of Young Patients with Chronic Hemolytic Conditions

Doulgeraki Artemis , Chatziliami Antonia , Athanasopoulou Helen , Polyzois Georgios , Petrocheilou Glykeria , Iousef Jacqueline , Karabatsos Fotis , Schiza Vasiliki , Fragodimitri Christina

Background: Chronic hemolytic anemias may compromise growth through multiple mechanisms. To date, no data exist on growth and body composition (BC; bone, muscle and fat mass) of children and adolescents with chronic hemolysis.Purpose: To evaluate growth and BC of patients with thalassemia intermedia (not on regular transfusions; thal-intermedia), alpha-thalassemia and congenital spherocytosis....

hrp0095p2-46 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Successful treatment with zoledronic acid of a 13-year-old boy with corticosteroid-induced osteoporosis after hematopoietic stem cell transplantation

Athina Vlachopapadopoulou Elpis , Bonataki Myrto , Doulgeraki Artemis , Polyzois Giorgos , Paisiou Anna , Goussetis Eugenios , Peristeri Ioulia , Michalacos Stefanos

Background: Allogeneic hematopoietic stem cell transplantation (HSCT) has emerged as an increasingly successful option to cure a variety of malignant disorders in children. Children benefit from improved survival; however, HSCT is associated with numerous acute and long-term toxicities. Osteoporosis is a well described, late effect of allogeneic HSCT, associated with corticosteroid treatment and patients exposed to cumulative doses >9000 mg/m2 of prednisone...

hrp0086p1-p115 | Bone & Mineral Metabolism P1 | ESPE2016

A European Survey to Identify New Roads for Care, Training and Research Around Rare Metabolic Bone Diseases

Fernandez Isabelle , Ahmed Syed Faisal , Bishop Nick , Brandi Maria Luisa , Doulgeraki Artemis , Haeusler Gabriele , Hogler Wolfgang , Kostik Mikhail , Makitie Outi , Moreno Gabriel Martos , Nilsson Ola , Schnabel Dirk , Šumnik Zdenek , Tillmann Vallo , Turan Serap , Zillikens Carola , Linglart Agnes , on behalf of the European Metabolic Bone Network

Background: Rare metabolic bone diseases (RMBD) are at the crossways of Endocrinology, Nephrology, Orthopaedic surgery and Rheumatology. Most of RMBD lead to short stature, bone pain, tooth anomalies, leg deformities, bone fragility and disability of variable importance. The organization of care varies immensely amongst European countries. Several European networks dedicated to RMBD already exist, supported by societies such as ESPE, ECTS or research grants, albeit their focus...