hrp0089p1-p019 | Adrenals and HPA Axis P1 | ESPE2018

The Usefulness of Combined Analysis of Serum and Salivary Maximum Cortisol Response to Low-Dose ACTH Test to Define the Requirement of Hormone Replacement Treatment

Vaiani Elisa , Lazzati Juan Manuel , Maceiras Mercedes , Gil Silvia , Costanzo Mariana , Zaidman Veronica , Dratler Gustavo , Belgorosky Alicia

Introduction: The low-dose synacthen test (LDT) is widely used to assess central adrenal insufficiency (CAI); however, the total serum cortisol (C) cut-off value is controversial. A correct diagnosis of CAI is required, but overdiagnosis may lead to unnecessary hormone replacement therapy. Salivary cortisol (SC) reflects the levels of free serum cortisol and is a noninvasive alternative.Objective: To define a new cut-off value of serum cortisol in pediat...

hrp0084p3-1176 | Thyroid | ESPE2015

Graves’ Disease in Childhood and Adolescence: Clinical Manifestations, Adverse Effects, and Predictive Factors for Response to Antithyroid Drugs

Dujovne Noelia Vanesa , Dratler Gustavo , Pitoia Fabian , Felipe Laura , Ayarzabal Victor , Soria Ianina , Berger Malena , Belgorosky Alicia , Herzovich Viviana

Background: Antithyroid drugs (ATD) are recommended as the initial treatment in Graves disease in childhood and adolescence. Identification of predictive factors might lead to improve patient management by facilitating the identification of patients requiring long-term ATD or early alternative therapy.Objective and hypotheses: To assess the prevalence of signs and symptoms of hyperthyroidism in childhood and adolescence, to evaluate the rates of adverse ...