ESPE Abstracts

ESPE Abstracts

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hrp0098p1-8 | Adrenals and HPA Axis 1 | ESPE2024

Leptin and adiponectin are associated with the glucocorticoid dose and androgen concentrations in children and young persons with congenital adrenal hyperplasia: data from the CAH-UK cohort.

A Bacila Irina , R Lawrence Neil , Alvi Sabah , D Cheetham Timothy , Crowne Elizabeth , Das Urmi , T Dattani Mehul , H Davies Justin , Gevers Evelien , Keevil Brian , E Krone Ruth , Lawrie Allan , Patel Leena , Randell Tabitha , J Ryan Fiona , Thankamony Ajay , Faisal Ahmed S , P Krone Nils

Introduction: Patients with Congenital adrenal hyperplasia (CAH) have increased prevalence of obesity and metabolic problems. The underlining mechanisms are not clearly known. Adipokines are likely involved in this association, however, their role in it is not completely understood.Objective: We studied adiponectin and leptin in children and young persons with CAH, in relation to their body mass, treatment, hormonal and ...
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hrp0098p1-107 | Adrenals and HPA Axis 2 | ESPE2024

Non-invasive biochemical monitoring for Congenital Adrenal Hyperplasia: use of urinary steroid metabolites and salivary 17α-Hydroxyprogesterone

J Tonge Joseph , Bacila Irina , Richard Lawrence Neil , Alvi Sabah , D Cheetham Timothy , Crowne Elizabeth , Das Urmi , Tulsidas Dattani Mehul , H Davies Justin , Gevers Evelien , Keevil Brian , E Krone Ruth , Patel Leena , Randell Tabitha , J Ryan Fiona , Thankamony Ajay , Faisal Ahmed S , Taylor Norman , P Krone Nils

Background: Monitoring disease control in congenital adrenal hyperplasia (CAH) by random serum 17a-Hydroxyprogesterone (17OHP) measurements is invasive and fails to capture total daily adrenal steroid synthesis. Urinary steroid analysis may provide a more suitable, non-invasive method of assessing treatment response in children with CAH, by estimating the total daily excretion of 17OHP metabolites.Method: Urine was colle...
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hrp0097fc1.5 | Adrenals and HPA Axis | ESPE2023

Management of congenital adrenal hyperplasia in the first 90 days of life: a multi-centre I-CAH analysis of contemporary practice

BN Lim David , Bryce Jillian , R Ali Salma , Tseretopoulou Xanthippi , H Birkebaek Niels , E Hannema Sabine , Campos-Martorell Ariadna , Clemente Maria , Neumann Uta , E Flück Christa , Metzger Sara , E Krone Ruth , German Alina , Baronio Federico , Atapattu Navoda , N Seneviratne Sumudu , Cools Martine , Mieke Théry , Guran Tulay , Yavas Abali Zehra , Fu Antony , Janus Dominika , Wasniewska Malgorzata , Coco Roberto , Russo Gianni , Rita Stancampiano Marianna , Bonfig Walter , Salerno Mariacarolina , L Claahsen-Van Der Grinten Hedi , PH Adriaansen Bas , Bachega Tania , Cavalieri Costa Fernanda , Marginean Otilia , De Sanctis Luisa , Probst Ursina , Lenherr-Taube Nina , Konrad Daniel , O’Connell Michele , Gawlik Aneta , E Sandberg David , Shnorhavorian Margarett , Krone Nils , Faisal Ahmed S , H Davies Justin

Aims: Historical I-CAH data shows considerable variation in the management of 21-hydroxylase deficiency (21-OHD) congenital adrenal hyperplasia (CAH) in infancy despite existence of several guidelines. Using the I-CAH registry we analysed contemporary early infancy natural history data, creating benchmarks as part of continuous quality improvement.Methods: Of 136 infants born in 2018-2023 and treated for 21-OHD CAH withi...
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