ESPE Abstracts

ESPE Abstracts

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hrp0084fc6.3 | Gonads & DSD | ESPE2015

Establishing the Role of the Steroid Backdoor Pathway for Androgen Biosynthesis in the Human Ovary

Marti Nesa , Sauter Kay S , Mullis Primus E , Fluck Christa E

Background: Recent work revealed two pathways in androgen biosynthesis, namely the classic and an alternative, the backdoor pathway. In this alternative pathway dihydrotestosterone is produced from 17-hydroxyprogesterone without the intermediacy of testosterone using mostly enzymes that are specific to the backdoor path. In the human ovary, regulation of androgen production plays a crucial role in normal physiology and in pathologies such as the polycystic ovary syndrome (PCOS...
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hrp0095p1-582 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

An International Study Of The Association Between Local Health Care Resources And Acute Adrenal Insufficiency Events In Children With Congenital Adrenal Hyperplasia

Tseretopoulou Xanthippi , R. Ali Salma , Bryce Jillian , Navoda Atapattu , H. Birkebaek Niels , Baronio Federico , Bonfig Walter , L. Claahsen-van der Grinten Hedi , Cools Martine , Darendeliler Feyza , Poyrazoglu Sukran , de Sanctis Luisa , Elsedfy Heba , J.J. Finken Martijn , E. Fluck Christa , Gevers Evelien , Korbonits Marta , Guran Tulay , Guven Ayla , A. Hughes Ieuan , Tadokoro-Cuccaro Rieko , Thankamony Ajay , Iotova Violeta , Krone Ruth , Lichiardopol Corina , B. Mendonca Berenice , A. S. S. Bachega Tania , C. Miranda Mirela , Milenkovic Tatjana , Mohnike Klaus , Nordenstrom Anna , J. van der Kamp Hetty , Faisal Ahmed Syed

Introduction: The reported occurrence and management of acute adrenal insufficiency (AI) – related adverse events (AE) vary widely between centres and may depend on available resources.Aim: To use the data within the I-CAH Registry to understand the association between the occurrence and management of AI related AE, their management and the availability of local resources.Methods:</st...
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