hrp0098p2-31 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

Bisphosphonates: A promising treatment for osteolytic lesion in Langerhans cell histiocytosis

Ho Cindy , Pian Tee Pian , Edward Puhaindran Mark , Chong Quah Thuan

Langerhans cell histiocytosis (LCH) represents a spectrum of rare disorders characterised by idiopathic infiltration and accumulation of abnormal histiocytes (i.e. the Langerhans cells) within various tissues. Bone is the most frequently affected tissue in children with LCH, with unifocal involvement being more common than multifocal involvement. Some of these lesions can cause severe pain and lead to pathological fractures. We describe a case series of 2 patients who had rece...