hrp0092rfc7.1 | Diabetes and Insulin Session 2 | ESPE2019

Accuracy of Glucose Sensor Estimate of HbA1c in Children with Type 1 Diabetes

Ehtisham Sarah , Adhami Sara

Introduction: Glucose sensor usage is increasing in the paediatric type 1 diabetes population. The sensor downloads can provide valuable information about glycaemic levels over a 90-day period and generate an estimated HbA1c based on the average glucose level.Aim: We aimed to test whether the sensor-estimated HbA1c over 90 days was an accurate prediction of the measured HbA1c and whether its accuracy correlated with perc...

hrp0097p2-24 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Familial growth hormone deficiency associated with a PROKR2 gene variant

El Hattab Ayman , Ehtisham Sarah

A 16 year old boy initially presented with short stature at age 6, with height <0.4th centile (HSDS -2.78). Bone age was 1.9 years delayed, and growth hormone deficiency was diagnosed after 2 stimulation tests. The rest of his pituitary function was normal. He never had pituitary imaging. Growth hormone treatment was started, and he had an excellent growth response with HSDS improving to -1.57 by 10 years. The growth hormone treatment was discontinued when the family reloca...

hrp0084p3-1178 | Thyroid | ESPE2015

Short Stature with Lipodystrophy: Reminder of a Forgotten Syndrome

Kumar Rakesh , Rifkin Robin , Ehtisham Sarah

Background: The combination of various severe manifestations of hypothyroidism with pseudo muscular hypertrophy is called Kocher Debre Semelaigne syndrome (KDS). KDS is very rare in countries where newborn screening for hypothyroidism is in place. Most of the reports of KDS have come from India and developing countries with only a single report from Europe over last five decades. We present a 7-year-old boy from UK who had short stature and apparent partial lipodystrophy.<...

hrp0097p2-147 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Posterior Sellar Spine - an unusual cause of precocious puberty

Samad Punekar Abdul , Shehab Mostafa , Ehtisham Sarah

A 7 year old girl presented with breast development, mood changes and rapid growth spurt from 6.5 years. Clinically she was tall for her family and had Tanner stage 2 breast development and pubic hair. Bone age was 3 years advanced and pelvic ultrasound demonstrated globular anteverted uterus with endometrial lining and enlargement of the ovaries with follicles. LHRH test confirmed central precocious puberty with peak LH 44mIU/ml and FSH 19mIU/ml, with baseline estradiol of 92...

hrp0092p3-183 | Multisystem Endocrine Disorders | ESPE2019

High Demand for Collaborative Work Between Paediatric Endocrinologists in Arab Countries

Alsaffar Hussain , Elawwa Ahmed , Aljaser Fahed , Chaturvedi Deepti , Ehtisham Sarah , Habeb Abdelhadi , Deeb Asma

Introduction: The Middle East and North Africa (MENA) region has witnessed increasing number of researchers over last decade; for example, in-between 2015 and 2016, the number of researchers (in full time equivalent) per 1 million inhabitants was 2.4K in UAE, 1.1K in Morocco, 680 in Egypt, 604 in Qatar and 242 in Oman. Research and Development investment among Arabic countries was the highest in Tunisia, Egypt, Morocco, Saudi Arabia and the United Arab Emirate...

hrp0084p2-486 | Hypo | ESPE2015

Transient Hyperinsulinaemic Hypoglycaemia in Association with a Novel ABCC8 Mutation: Expanding the Clinical Phenotypes

Arya Ved Bhushan , Aziz Qadeer , Mohamed Zainaba , Flanagan Sarah E. , Ellard Sian , Ehtisham Sarah , Tinker Andrew , Hussain Khalid

Background: Hyperinsulinaemic hypoglycaemia (HH) can be transient or permanent. Transient HH (spontaneous resolution of HH within few weeks) is associated with intrauterine growth restriction, maternal diabetes, erythroblastosis fetalis etc. Transient HH has not been reported with ABCC8/KCNJ11 mutations, which are the commonest cause of HH.Aim: Molecular characterisation of a novel ABCC8 mutation associated with a transient HH phenotype seen in a family ...