hrp0089p3-p089 | Diabetes & Insulin P3 | ESPE2018

A Female Patient with Atypical Diabetes Features, Showing Heterozygous Mutations on G6PC2 (Glucose 6 Phosphatase, Catalytic Subunit 2): Does Explain All Clinical Manifestations or Is It Only Polymorphism?

Ozsu Elif

A female patient with atypical diabetes features, showing heterozygous mutations on G6PC2 (Glucose 6 phosphatase, catalytic subunit 2). Does explain all clinical manifestations or is it only polymorphism?Introduction: Determing diabetes subtypes and classification is not clear for every patient and diagnosis can be difficult. Here in, we have found a quite interesting mutation on G6PC2 gene in a girl, 10 years old, showing atypical diabetes characteristi...

hrp0086p2-p509 | Fat Metabolism and Obesity P2 | ESPE2016

Which Marker is the Most Reliable One for the Detection of NAFLD in Outpatient Clinic?

Ozsu Elif , Yazicioglu Bahadir

Background: Non-alcoholic fatty liver disease (NAFLD) has become a public health issue because its incidence increased threefold during the last 3 decades among children and adolescents. Although liver biopsy is the gold standard to determine NAFLD, its applicability is low in childhood. Thus, some noninvasive markers are being used more commonly.Objective and hypotheses: We aimed to find the most reliable marker to detect NAFLD in routine examination.</...

hrp0082p2-d3-406 | Fat Metabolism &amp; Obesity (2) | ESPE2014

Relationship Between Obesity and Platelet Indices in Children

Ozsu Elif , Yazicioglu Bahadir

Background: Platelet levels plays a key role for determining insulin resistance by a simple test. The degree of platelet activation may be assessed by platelet indices such as platelet count, mean platelet volume (MPV), and platelet distribution width (PDW).Objective and hypothesis: The aim of this study is to assess platelet count, MPV, and PDW as metabolic indicator in obese chlidren with or without insulin resistants.Methods: Tw...

hrp0086p2-p304 | Diabetes P2 | ESPE2016

Cardiovascular Risk and Long Term Follow-up of Turkish Children with Type 2 Diabetes: Single Center Experience

Guven Ayla , Demir Elif Gokce

Background: Type 2 diabetes (T2DM) increases in parallel with obesity in childhood. T2DM can be associated with cardiovascular risk (CVR) even childhood.Objective: To investigate the presence of CVR criterions in children with T2DM and to detect CVR as the earliest age as possible.Method: This study enrolled 84 (58 Girls) children with T2DM. OGTT was performed in 47 children. Biochemical and hormonal analyses were performed in fast...

hrp0089p2-p176 | Fat, Metabolism and Obesity P2 | ESPE2018

Identification of A Novel Homozygous Mutation in BBS10 in Five Children With Bardet-Biedl Syndrome

Yilmaz Gulay Can , Keskin Ece , Sobu Elif

Bardet-Biedl syndrome (BBS) is a rare and multisystemic disorder characterized by rod-cone dystrophy, post-axial polydactyly, learning difficulties, renal abnormalities, obesity and hypogonadism. The disorder is genetically heterogeneous. To date, 21 genes present on different chromosomes have been mapped. The most common genes are BBS1 (locus 11q13) and BBS10 (locus 12q21.2). We aimed to report two family with five affected children with typical clinical features of Bardet-Bi...

hrp0089p3-p365 | Thyroid P3 | ESPE2018

The Reference and Follow-up Signs and Symptoms of the Cases Who Are Diagnosed As Hyperthyroidism

Gokce Demir Elif , Guven Ayla , Yildiz Metin

Objective: Hyperthyroidism is rarely seen in the childhood. In this study, we evaluated the reference sign and symptoms and following laboratory and treatment results of the hyperthyroidism cases.Method: Data of the 78 patients were extracted from hospital records retrospectively. Patients’ height, weight, BMI and laboratory results at the time of diagnosis are recorded. Antithyroid drug doses at the 2th, 6th, 12th months after diagnoses are compare...

hrp0094p1-177 | Growth Hormone and IGFs B | ESPE2021

Immunogenicity of recombinant growth hormone and relationship its growth-promoting effect in the children with short stature

Karaoglan Murat , Isbilen Elif , Keskin Mehmet ,

Background/Aim: Although there are many well-known components that affect the growth response to recombinate growth hormone (rGH), its effect on total height gain is still not fully predictable. Current knowledge on the relationship between growth response to rGH and its immunogenicity is limited. The aim of the study was to reveal its relationship with the antibody formation against rGH and growth-promoting effect.Materials and Methods:...

hrp0094p2-269 | Growth hormone and IGFs | ESPE2021

Immunogenicity of recombinant growth hormone therapy in the children with short stature and consequences on growth-promoting effect

Karaoglan Murat , Isbilen Elif , Keskin Mehmet ,

Background/Aim: Although there are many well-known components that affect the growth response to recombinant growth hormone (rGH), its effect on total height gain is still not fully predictable. A limited number of studies have been reported revealing up-to-date data on the relationship between immunogenicity and growth-promoting effects of rGH. The study aimed to examine the antibody formation against rGH and its consequences on growth-promoting effect in chi...

hrp0082p2-d2-271 | Adrenals &amp; HP Axis (1) | ESPE2014

The Results of CYP21A2 Mutation Analysis in Adolescent with Polycystic Ovary Syndrome

Yagli Colakoglu Elif , Bulus Derya , Andiran Nesibe , Ufuk Isin Ugur

Background: Diagnosis of polycystic ovary syndrome (PCOS) in the adolescent is difficult due to high background rate of menstrual irregularity, high prevalence of polycystic morphology and hyper and rogenic features in this population. Also late onset congenital adrenal hyperplasia (LOCAH) mimics PCOS in this period. It is important to distinguish these entities because of the differences in their therapy. The study aimed to find out the frequency of LOCAH in patients who diag...

hrp0082p2-d2-580 | Sex Development (1) | ESPE2014

The V89L Polymorphism in the SRD5A2 Gene in Cases with Undescended Testis

Yesilada Elif , Akinci Aysehan , Gulbay Gonca , Yuksel Sengul , Savaci Serap

Background: Steroid 5α-reductase catalyzes the conversion of testosterone into the more active androgen, dihydrotestosterone (DHT). In 46, XY patients with recessive mutations in steroid 5α-reductase type 2 enzyme (SRD5A2) gene, the degree of ambiguity ranges from isolated hypospadias to severe undermasculinization. SRD5A2 gene is located on chromosome 2 (p23 region) and is comprised of five exons and four introns.Objective and hypotheses: Mult...