hrp0082fclb3 | Late Breaking Abstracts | ESPE2014

Parent-of-Origin Specific Allelic Associations Among 106 Genomic Loci for Age at Menarche

Perry John , Day Felix , Elks Cathy , Sulem Patrick , Stefansson Kari , Murabito Joanne , Ong Ken

Background: Age at menarche in girls varies widely between individuals, is a heritable trait and is associated with risks for adult obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality.Objective and Hypotheses: The mechanisms that determine pubertal timing and underlie its links to later disease remain unclear.Method: We performed a genome-wide association study meta-analysis of genome-wide or den...