hrp0084p1-111 | Puberty | ESPE2015

Serum Neurokinin B Level can be Used to Differentiate Central Precocious Puberty from Premature Thelarche

Parlak Mesut , Turkkahraman Doga , Ellidag Hamit Yasar , Parlak Ayse Eda

Background: Neurokinin B and kisspeptin appear to play main roles in puberty.Aims and objectives: The aim of the present study was to investigate the diagnostic role of kisspeptin and neurokinin B in central precocious puberty (CPP) and premature thelarche (PT).Methods: The girls who presented with breast development (between 5 and 8 years) were included in the study. All cases underwent bone age (BA) assesment. Basal serum FSH, LH...

hrp0084p2-180 | Adrenals | ESPE2015

High-Dose Hook Effect in 17- Hydroxyprogesterone Assay in 21-Hydroxylase Deficiency

Parlak Mesut , Turkkahraman Doga , Parlak Ayse Eda , Ellidag Hamit Yasar

Background: False-negative results can occur an extremely high level of substrate at the assay system. This is called the ‘high-dose hook effect’.Case presentation: 14 year-old female patient was referred with short stature, amenorea and hirsutism. Height, weight and blood pressure were 140.5 cm (SDS:−3.5), 43.4 kg (SDS:−1.6) and 120/80 mmHg. She had stage 1 Tanner breast, stage 5 pubic hair and hirsutism (mFG scale: 28) with androi...