hrp0098p1-46 | Fat, Metabolism and Obesity 1 | ESPE2024

Circulating levels of ghrelin in patients with a rare disease with intellectual disability associated with hyperphagia, and/or overweight, and/or obesity – The HOGRID study

Brochado Cathy , Clerc Alice , Benvegnu Grégoire , Diene Gwenaëlle , Jouret Béatrice , Montastier Emilie , Grunenwald Solange , Molinas Catherine , Faye Sandy , Valette Marion , Tauber Maïthé

Introduction: The prevalence of overweight and/or obesity is approximately 2 times higher in people with intellectual disability (ID). Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder linked to hypothalamic dysfunction. People with PWS display ID and a characteristic nutritional trajectory ranging from anorexia to hyperphagia, leading to early severe obesity. Other rare diseases with ID are associated with eating disorders and overweight. Toda...