hrp0095p1-39 | Diabetes and Insulin | ESPE2022

Case report: Suppression of gonadotropins with contraceptives in type A insulin resistance ameliorates virilizing insulin-induced hyperandrogenism

Raeder Helge , Engebretsen Martine , Førsvoll Jostein

Insulin-induced ovarian hyperstimulation and hyperandrogenization can cause virilization in children and adults. It rarely occurs in children and adolescents but when it does, it is usually caused by congenital adrenal hyperplasia or virilizing tumors. In very rare cases severe hyperandrogenism is caused by severe insulin resistance, either due to germline mutations in genes encoding the insulin receptor or proteins in downstream insulin signaling or due to insulin receptor an...