hrp0084p1-67 | Fat | ESPE2015

miR-146a-Mediated Suppression of the Inflammatory Response in Human Adipocytes

Roos Julian , Enlund Eveliina , Tews Daniel , Funcke Jan-Bernd , Zoller Verena , Debatin Klaus-Michael , Wabitsch Martin , Fischer-Posovszky Pamela

Background: microRNAs (miRNAs) are a class of small (18–25 nucleotides), non-coding RNA molecules. They play an important role in the regulation of gene expression by either suppressing translation of genes or inducing their mRNA degradation. Several miRNA species are expressed in adipose tissue and involved in adipocyte function.Objective and hypotheses: Obesity leads to the infiltration of macrophages into adipose tissue causing local inflammation...