hrp0095p1-419 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Early-Stage Radiological Markers of Endothelial Dysfunction and Cardiovascular Findings in Patients with Osteogenesis Imperfecta and Their Genotype-Phenotype Correlations: A Case-Control Study

Evin Ferda , Aydin Derya , ÖZen Samim , Darcan Şükran , Onay Hüseyin , Gökşen Damla , Levent Ertürk

Introduction: Osteogenesis imperfecta (OI) is a disease related to collagen synthesis or fuctions. Collagen is found in many areas of the cardiovascular system. Endotelial dysfunction can be detected at an early stage before the symptoms become evident by non-invasive radiologic methods such as flow-mediated dilatation (FMD), carotid intima-media thickness (CIMT), and ventricular functions measurements, which may serve as indicators of endothelial dysfunction....

hrp0095p1-467 | Fat, Metabolism and Obesity | ESPE2022

The Level of Inflammatory Markers and their Relationship with Fat Tissue Distribution in Children with Obesity and Type 2 Diabetes

Akalın Ertürk Beyza , Gülbahar Özlem , Kaynak Şahap Seda , Saadet Deveci Bulut Tuba , Çetinkaya Semra , Savaş Erdeve Şenay

Introduction: Chronic inflammation is closely associated with metabolic disorders such as obesity, insulin resistance and Type 2 DM, and is dependent on abnormal cytokine production and activation of inflammatory signaling pathways. Adipose tissue is a metabolically active organ that can be a source of low-grade chronic inflammation in obese individuals. Our aim in this study; to determine whether there are changes in proinflammatory and antiinflammatory cytok...