hrp0089p1-p087 | Diabetes & Insulin P1 | ESPE2018

Investigation into β-cell Adaptation During Puberty

Castell Anne-Laure , Ethier Melanie , Fergusson Grace , Ghislain Julien , Poitout Vincent

Background: Puberty is a time of hormonal changes that are associated with insulin resistance. Although insulin sensitivity is restored at the end of puberty in healthy youth, it does not resolve in obese adolescents leading to an increase of cardio metabolic disease such as type 2 diabetes. In response to an increase in insulin demand, as during pregnancy or obesity-induced insulin resistance, β-cells increase their functional mass to maintain glucose homeostasis. Howeve...