hrp0098p2-19 | Adrenals and HPA Axis | ESPE2024

Metabolic risk factors in children with Premature Adrenarche – a systematic review and meta-analysis

Ben Said Wogud , Lempesis Ioannis , Fernandez Garcia Silvia , Thangaratinam Shakila , Arlt Wiebke , Idkowiak Jan

Background: Early onset of androgen excess in pre-pubertal children is usually caused by called premature adrenarche (PA). PA is characterised by the development of pubic and axillary hair, adult-type body odour in girls <8yrs and in boys <9yrs. PA may be a forerunner condition of polycystic ovary syndrome (PCOS), a complex metabolic disorder also characterised by androgen excess. Women with PCOS have higher risk of developing type 2 diabetes, dyslipidae...