ESPE Abstracts

Premature adrenarche (PremA), is associated to increased adiposity and in girls to earlier puberty and adverse metabolic profiles. Recently, the use LC-MS/MS studies demonstrated adrenal production of more potent androgens:11-oxygenatedC19 steroids. Defining the mechanisms that regulate adrenal C19 steroid production has been elusive. We recently showed that genetic determinants of DHEAS during adrenarche differed from those identified during adulthood. One top variant was at ...