hrp0092fc15.2 | Late Breaking Abstracts | ESPE2019
Gong Maolian
, Yu Yong
, Vuralli Dogus
, Fröhler Sebastian
, Kühnen Peter
, Du Bois Philipp
, Zhang Jingjing
, Hussain Khalid
, Fielitz Jens
, Jia Shiqi
, Chen Wei
, Raile Klemens
Background: Studying patients with rare Mendelian diabetes has highlighted molecular mechanisms regulating β-cell pathophysiology. Previous, experimental studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell differentiation, function and finally glucose homeostasis.Methods: We performed exome sequencing in one adolescent boy with non-autoimmune di...