hrp0086p2-p423 | Gonads & DSD P2 | ESPE2016

Sisters with 46XY Gonadal Dysgenesis and Gonadoblastoma

Petychaki Foteini , Vlachopapadopoulou Elpis , Dikaiakou Eirini , Mpaka Margarita , Kitsiou-Tzeli Sofia , Mavrou Ariadni , Michalakos Stefanos

Background: 46XY DSD with female phenotype is classified as complete gonadal dysgenesis (46XY CGD) if a uterus is present or a disorder of androgen synthesis or action if a uterus is absent. The genetic causes of 46XY CGD are not fully clarified. Less than 15% of the cases were found to carry mutations of the sex determining region Y gene (SRY).Purpose: The description of the rare case of two sisters affected of 46XY CPD and gonadoblastoma with SRY mutat...

hrp0086p2-p490 | Fat Metabolism and Obesity P2 | ESPE2016

Matsuda Index in Correlation with Clinical Indicators of Insulin Resistance in Children and Adolescents

Dikaiakou Eirini , Vlachopapadopoulou Elpis , Petychaki Foteini , Patinioti Ioanna , Anagnostou Elli , Karachaliou Feneli , Kafetzi Maria , Fotinou Aspasia , Michalacos Stefanos

Background: Obesity-related insulin resistance is present in obese children and Matsuda index is a method proposed to evaluate insulin resistance, using data obtained from the oral glucose tolerance test (OGTT).Objective and hypotheses: To investigate whether the clinical indicators of family history of obesity and/or Type II diabetes, acanthosis nigricans, and increased waist circumference are associated with insulin resistance, as calculated by the Mat...