hrp0094p2-406 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021
McGlacken-Byrne Sinéad M
, Le Quesne Stabej Polona
, Del Valle Torres Ignacio
, Ocaka Louise
, Gagunashvili Andrey
, Crespo Berta
, Moreno Nadjeda
, James Chela
, Bacchelli Chiara
, Dattani Mehul
, Williams Hywel J
, Kelberman Dan
, Achermann John C
, Conway Gerard S
Background: Primary ovarian insufficiency (POI) affects 1% of women and is associated with significant medical consequences. In approximately 10% of cases, POI presents early with absent puberty or primary amenorrhoea. A genetic cause for POI can be found in up to 30% of women. Identified genes often relate to the complex biological processes occurring in fetal life which underpin normal ovary development and function in later adulthood.Objective: We aim...