hrp0098p1-111 | Adrenals and HPA Axis 2 | ESPE2024

Investigating Changes in Plasma Aldosterone Concentrations Following ACTH Stimulation in Healthy Individuals: A Systematic Review and Meta-Analysis on the Influence of ACTH on Aldosterone Secretion

Stathori Galateia , Alexakis Dimitrios , Panagiotis Chrousos George , Paltoglou George

Adrenocorticotropic hormone (ACTH) in addition to renin-angiotensin- aldosterone axis is a potent aldosterone stimulator, suggesting a potential contribution in conditions associated with increased ACTH concentrations. This review aims to systematically review and synthesize the scientific evidence of alterations of plasma aldosterone concentrations in response to ACTH stimulation during the cosyntropin (Synacthen) test and define the range of aldosterone response. A systemati...