hrp0098fc1.5 | Diabetes and Insulin | ESPE2024

The Side-Effects of Lanreotide in Children with Congenital Hyperinsulinism (CHI): A Decade-long Exploration

Malhotra Neha , Yan Georgina , Morgan Kate , Gilbert Clare , Doodson Louise , Gan Chin , Dastamani Antonia

Background: Lanreotide, a prolonged-release somatostatin analogue, has been utilized off-label for nearly a decade to treat cases of congenital hyperinsulinism (CHI) that do not respond to diazoxide. Acute side-effects of Lanreotide include diarrhoea and topical allergic reactions. Long-term effects include hepatitis, gallstones, growth suppression, hypothyroidism and gastrointestinal dysmotility. However, limited number of case series have documented the long...