hrp0092p1-26 | Diabetes and Insulin | ESPE2019

Myocardial Function in Asymptomatic Children with Type 1 Diabetes

Barakizou Hager , Gannouni Souha

Introduction: Diabetic cardiomyopathy is defined as myocardial dysfunction which is independent from any other ischemic, valvular or hypertensive etiology. It is a multifactorial condition caused mainly by a change in the myocardial structure leading sometimes to fibrosis especially in patients with poor diabetes control.Aim: To assess whether type 1 diabetic children and adolescents have early echocardiographic signs of...

hrp0092p3-196 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Precocious Pseudo-Puberty Presenting with Bilateral Ovarian Involvement and Progressing to Juvenile Granulosa Cell Tumor in a 2-Year-Old Girl

Barakizou Hager , Donaldson Malcolm , Huma Zilla , Amary Fernanda , Gannouni Souha

Background: Feminising preocious pseudo-puberty in McCune Albright syndrome (MAS) and juvenile granulosa cell tumour (JGCT) arises from bilateral and unilateral estradiol hypersecretion respectively. GNAS mutations have been described in some cases of JGCT as well causing MAS.Aim: To describe a case in which MAS was evoked initially, but then progressed to JGCTCase: A girl aged 2 y...