hrp0086p1-p825 | Syndromes: Mechanisms and Management P1 | ESPE2016

Screening of Birth Length and Parental Height Detects Infants with Poor Catch-Up Growth at Age 2 Years

Sardar Colette Montgomery , Donnelly Sharon , Siddique Jamila , Kinmond Sheena , Gault Emma Jane , Donaldson Malcolm

Background: A programme of measuring birth length (BL) and parental heights (PH) for neonates classified as Small for Gestational Age (SGA, Birth Weight (BW) <9th centile, UK 1990 reference data) has been adopted in one Scottish hospital since 2008. Neonates with Short Stature (BL≤−2 standard deviation scores/SDS) are invited for re-measurement of weight and height at age 2 years, thus making medical services aware of individuals who have not had ade...

hrp0084wg6.4 | Turner Syndrome | ESPE2015

Management of Middle Ear and Hearing Problems in Turner Syndrome – How Can We Do Better?

Lim David , Donaldson Malcolm , Gault Emma Jane , Clement Andrew , Kubba Haytham , Mason Avril

Background: Otological problems in Turner syndrome (TS) are notoriously common and troublesome, often requiring intervention with adeno-tonsillectomy, insertion of ventilation tubes and occasionally resulting in serious disease such as cholesteatoma.Survey of otological problems in the West of Scotland: A case note review of 174 girls attending the Turner clinic in Glasgow, Scotland from 1989–2015 found that of 155 patients in whom data were availab...

hrp0084p2-548 | Puberty | ESPE2015

Sensitivity of Measured Parental Height and Target Range in the Diagnosis of Turner Syndrome

Ouarezki Yasmine , Cizmecioglu Filiz , Mansour Chourouk , Jones Jeremy , Gault Emma Jane , Mason Avril , Donaldson Malcolm

Background: Girls with Turner syndrome (TS) are inappropriately short for their parents’ heights; measured parental height is therefore useful in diagnosis.Objective and hypotheses: To examine the sensitivity of measured parental height in the diagnosis of TS; and to audit the frequency of parental height measurement in our clinic.Method: Case note review of all girls with TS attending our dedicated Turner clinic between 1989&...

hrp0084p3-1011 | Growth | ESPE2015

Targeted Birth Length and Parental Height Measurement in Babies with Birthweight≤9th Centile; Improved Uptake During Second Study During 1 Calendar Year in a Single Newborn Unit

Sardar Colette Montgomery , Donnelly Sharon , Siddique Jamila , Gault Emma Jane , Kinmond Sheena , Donaldson Malcolm

Background: The contribution of intrauterine growth restriction (IUGR) and parental height (PH) to childhood short stature is difficult to determine in countries, including the UK, where birth length (BL) is not routinely measured, while accurate PH may become unavailable due to separation/divorce. A previous study (2008–2009) examined the feasibility of BL and PH measurement in the lightest 9% of babies born in a single maternity unit. Uptake was disappointing, with part...

hrp0084fc4.3 | Growth | ESPE2015

An Updated and Final Analysis of a Randomised Placebo-controlled Trial of the Effect of Oxandrolone and Timing of Pubertal Induction on Final Height in Turner Syndrome

Gault Emma-Jane , Cole Tim J , Perry Rebecca J , Casey Sarah , Paterson Wendy F , Hindmarsh Peter C , Betts Peter , Dunger David B , Donaldson Malcolm D C

Background: While GH therapy forms the mainstay of growth promoting treatment for Turner syndrome (TS), adjunctive use of oxandrolone and optimal timing of pubertal induction remain controversial. The previously published interim analysis of this randomised double-blind placebo-controlled trial demonstrated that oxandrolone and pubertal induction at 14y vs 12y significantly increased final height. However, these effects were not additive.Objective: To up...