hrp0084p3-1109 | Pituitary | ESPE2015

Acute Phase Proteins and Endocrine Dysfunction after Traumatic Brain Injury in Childhood

Verigaki Olga , Papassotiriou Ioannis , Prodromou Neofytos , Sfakianos George , Chrousos George , Kanaka-Gantenbein Christina

Background: Endocrine impairments, such as diabetes insipidus (DI), growth hormone deficiency (GHD) and, to a lesser degree, thyroid or cortisol deficiencies, have been reported after traumatic brain injury (TBI) in adults and much less in children both at the acute post-traumatic phase and after a lag period of time. However, no prospective data exist on the endocrine and acute phase protein response to TBI in childhood.Aim/objective: To unravel possibl...

hrp0082fc6.1 | Gonads & DSD | ESPE2014

Search for Genetic Defects in the Transcription Factor Genes FOXL2, FOXE1, BMP15, NOBOX, and GDF9 in Children, Adolescents and Young Adults With Premature Ovarian Insufficiency POI

Settas Nikolaos , Anapliotou Margarita , Deligeoroglou Euthimios , Kanavakis Emmanuel , Fryssira Eleni , Kanaka-Gantenbein Christina , Michala Lina , Dacou-Voutetakis Catherine , Creatsas George , Chrousos George P , Voutetakis Antonis

Background: Molecular defects are rarely detected in Premature ovarian insufficiency (POI) patients.Objective and Hypotheses: We hypothesized that the frequency of causative molecular defects could be higher in cases with early onset of POI. Moreover, the analysis of multiple genes in the same POI group could disclose co-existence of more than one molecular aberration.Method: In 25 subjects, aged 17.1±7 years at POI onset, bid...

hrp0092p3-181 | Multisystem Endocrine Disorders | ESPE2019

Phenotype and Clinical Course in Three Individuals with Multiple Endocrine Neoplasia Type 2A due to a RET Gene Mutation

Panou Evangelia , Chrousos George

Background: Mutations in the RET gene have been described in subjects with multiple endocrine neoplasia Type 2 (MEN 2A). MEN 2A is a rare autosomal dominant disorder characterized by tumors of the C cells of the thyroid, adrenal medulla and parathyroid glands. Patients develop either C-cell hyperplasia or medullary thyroid cancer, pheochromocytoma, and in some cases hyperparathyroidism.Objective/Method: To descr...

hrp0092p2-204 | Multisystem Endocrine Disorders | ESPE2019

Electromagnetic Fields Exposure in Adolescents: A Survey in 11-14 y Old Greek Students

Geronikolou Styliani , Chrousos George , Kanaka-Gantenbein Christina

Background: Electromagnetic field (EMF) exposure has been considered a potential environmental toxicant, which may influence endocrine and other functions, while population awareness remains limited. In an earlier study, we demonstrated that EMF alters the hypothalamic-pituitary-adrenal axis in children using a 3G mobile telephone.Aim: To screen and compare the motives, knowledge and status of electromagnetic field expos...

hrp0089p3-p279 | Multisystem Endocrine Disorders P3 | ESPE2018

Near Electromagnetic Fields – Induced Syndrome: Unsuspected and Newly Recognised

Geronikolou Styliani , Chrousos George , Kanaka-Gantenbein Christina

This present study investigates the impact of a common environmental hazard, the radiofrequency fields (RF), such as those regarding cell phones, cell phone base stations, wi-fi, portable phones (DECT), etc., as close to the body sources of exposure, on endocrine function. This is of importance, particularly for developing children, that have been and are exposed to this potential hazard. We performed analyses on endocrine assessments regarding stress, thyroid hand reproductiv...

hrp0095p1-30 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Vitamin D may facilitate Clock/Bmal1-DNA interactions in a Vitamin D receptor-independent fashion

Nicolaides Nicolas , Papakonstantinou Eleni , Vlachakis Dimitrios , Chrousos George

Background: The Clock/Bmal1 transcription factor heterodimer regulates the circadian activities of many biological systems, including the hypothalamic-pituitary-adrenal (HPA) axis, by trans-activating or trans-repressing downstream target genes. 1,25 Dihydroxy Vitamin D (Vitamin D), a sterol hormone that is activated by exposure to sunlight, plays a fundamental role in maintaining calcium and phosphorus homeostasis. Recent evidence suggests that the nuclear vi...

hrp0092fc13.6 | Adrenals and HP Axis | ESPE2019

Insights Into the Role of Cortisol in the Formation of the Clock/Bmal1 Complex and its Interaction with dsDNA, via Molecular Dynamics Simulations

Nicolaides Nicolas , Raftopoulou Sofia , Kino Tomoshige , Vlachakis Dimitrios , Chrousos George

Background: The circadian rhythm-generating peripheral Clock/Bmal1 heterodimer complex regulates the circadian activities of many biological systems, including the hypothalamic-pituitary-adrenal (HPA) axis, by trans-activating or trans-repressing downstream target genes.Objective and Hypotheses: To investigate the potential role of elevated cortisol in Clock/Bmal1 heterodimer complex-generated circadian biorhythms, both ...

hrp0089p3-p197 | GH & IGFs P3 | ESPE2018

Adherence and Long-term Outcomes of Therapy in Pediatric Subjects in Greece Using Easypod™ Electromechanical Device for Growth Hormone Treatment: The Phase IV Multicentre Easypod™ Connect Observational Study (ECOS)

Charmandari Evangelia , Michalakos Stefanos , Sakellariou Dimitris , Koledova Ekaterina , Chrousos George

The Easypod™ Connect Observational Study (ECOS) was the first global study of easypod™, currently the only electronic injection device for recombinant human growth hormone (r-hGH; Saizen®). ECOS reported accurate and robust real-time adherence data in a large cohort of patients. In this analysis, we assess the adherence of r-hGH administered via easypod™ in a cohort of Greek patients from ECOS (EMR200104-520, NCT01363674). Patients aged 2–18...

hrp0086rfc5.8 | Management of Disorders of Insulin Secretion | ESPE2016

Stress Management and Health Promotion through Family Intervention Improves Metabolic Control in Children and Adolescents with Type 1 Diabetes

Panayi Laura , Kanaka-Gantenbein Christina , Darviri Christina , Chrousos George P.

Background: Optimal glycemic control in children and adolescents with type 1 diabetes mellitus (T1DM) is often hampered owing to psychologic maladjustment of both patients and their parents. Accumulating evidence suggests that hyperglycemia may be associated with prolonged activation of the stress system.Objective and hypotheses: To pilot test a 12-week intervention program including psychoeducation about stress, healthy lifestyle, diaphragmatic breathin...

hrp0082fc12.5 | Obesity | ESPE2014

Low Circulating Levels of DKK-1 Protein in Obese Children Indicate Suppression of Canonical Wnt Signaling

Kanaka-Gantenbein Christina , Terpos Evangelos , Chrousos George , Papassotiriou Ioannis

Background: Secretion of Wnt-proteins by adipose cells plays an important role in the control of adipogenesis. The Wnt-antagonist, dickkopf-1 (DKK-1), is secreted by human pre-adipocytes and influences adipocyte maturation and growth. DKK-1 mRNA increases 6 h after onset of human adipogenesis followed by an increase in DKK-1 protein. Of note, DKK-1 protein has been implicated also in bone remodeling pathways.Patients and Methods: In this study we measure...