hrp0094p2-34 | Adrenals and HPA Axis | ESPE2021

Maternal primary adrenal cortex insufficiency during pregnancy: Spotlight on the Fetus and the Neonate. A systematic review and meta-analysis.

Ilia Georgia , Paltoglou George , Chatzakis Christos , Christopoulos Panagiotis , Mastorakos George ,

Background/Aim: Maternal primary adrenal insufficiency, has been infrequently described during pregnancy, due to its rarity. Based on the existing literature, maternal hormone deficiency influences pregnancy and has an impact on mother and fetus/neonate, with only a few studies emphasizing on the respective outcomes. The aim of this systematic review and meta-analysis was to evaluate the impact of maternal corticosteroid deficiency during pregnancy on the fetu...

hrp0095p1-448 | Diabetes and Insulin | ESPE2022

The effect of physical activity on leptin and adiponectin in youth with T1D

Kaza Maria , Tsentidis Charalambos , Vlachopadopoulou Elpis , Sakou Ikboule , Paltoglou George , Mastorakos George , Karavanaki Kyriaki

Introduction: Exercise has pleiotropic positive effects for children and adolescents with Type 1 Diabetes (T1D). It improves glycemic control, daily insulin requirements, quality-of-life, morbidity and mortality rate. Leptin and adiponectin are adipocytokines produced by adipose tissue cells. Adiponectin is anti-atherogenic, anti-diabetic and anti-inflammatory, whereas leptin induces insulin resistance, has thermoregulatory properties and is pro-inflammatory.<...

hrp0095p1-455 | Diabetes and Insulin | ESPE2022

An Adolescent with HNF1B Deletion. A Case Report

Vourdoumpa Aikaterini , Koutaki Diamanto , Vasilakis Ioannis-Anargyros , Bacopoulou Ioanna , Sertedaki Amalia , Charmandari Evangelia , Paltoglou George

Introduction: Mutations in hepatocyte nuclear factor 1Β (HNF1B) gene (chromosome 17q12), lead to monogenic diabetes (HNF1B-MODY or MODY5, OMIM 137920) accompanied by multisystem disorders. HNF1B gene encodes HNF1B protein, a member of the homeodomain-containing superfamily of transcription factors, expressed early in embryogenesis, contributing significantly to organogenesis and the function of many systems (kidneys, liver, panc...

hrp0095p1-271 | Fat, Metabolism and Obesity | ESPE2022

Serum Osteopontin, NGAL and Sclerostin concentrations in children and adolescents with overweight and obesity

Karampatsou Sofia-Iliada , Paltoglou George , Genitsaridi Sofia-Maria , Kassari Penio , Charmandari Evangelia

Background: Obesity in childhood and adolescence represents a major health problem and is associated with significant morbidity and mortality in adult life. Osteopontin, NGAL and Sclerostin are bone biomarkers, however, little is known about their role in obesity.Objective and Hypothesis: The aim of our study was to determine the concentrations of Osteopontin, NGAL and Sclerostin in children and adolescents with overweig...

hrp0095p1-481 | Fat, Metabolism and Obesity | ESPE2022

Non-traditional cardiometabolic risk factors in obese children and adolescents with Metabolic Syndrome

Tragomalou Athanasia , Paltoglou George , Tsitsiloni Ourania , Loukopoulou Sofia , Binou Maria , Ramouzi Eleni , Kassari Penio , Charmandari Evangelia

Background: The prevalence of obesity in childhood has increased dramatically during the last decades. Dyslipidemia, hypertension and insulin resistance – all components of the metabolic syndrome (MS) and well-known cardiometabolic risk factors – predispose to the development of inflammation and premature atherosclerotic cardiovascular disease in childhood.Aim: To determine “non- traditional” card...

hrp0095p2-107 | Fat, Metabolism and Obesity | ESPE2022

An Obese Patient with A Pathogenic PTEN Mutation. A Case Report

Vourdoumpa Aikaterini , Koutaki Diamanto , Paltoglou George , Fryssira Elena , Charmandari Evangelia , Bacopoulou Ioanna

Introduction: Germline mutations in Phosphatase and tensin homolog (PTEN) gene (chromosome 10q23) lead to PTEN Hamartoma Tumor Syndrome (PHTS), which includes Cowden syndrome. PTEN encodes a tumor suppressor protein that is a negative regulator of PI3K – Akt signaling pathway, taking part in multiple biological processes, including cellular cycle and regulation of metabolism.Materials and Methods:...

hrp0095p2-122 | Fat, Metabolism and Obesity | ESPE2022

Pediatric Endocrine evaluation of Marfan syndrome: A case report

Koutaki Diamanto , Vourdoumpa Aikaterini , Bacopoulou Ioanna , Fryssira Helen , Charmandari Evangelia , Paltoglou George

Background: Endocrine disorders associated with tall stature in childhood are frequently evaluated by Pediatric Endocrinologists. The most common non-endocrine genetic cause of tall stature, Marfan syndrome, is a rare autosomal dominant genetic condition of the connective tissue, which presents with specific dysmorphic features, including thin physique, long extremities and normal growth rate. Little is known regarding the association of Marfan syndrome with o...

hrp0089p1-p210 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Hypothalamic-pituitary-testicular Axis Response to Sub-maximal Aerobic Exercise, in Pre- and Early- Pubertal Normal Weight and Obese Boys

Paltoglou George , Avloniti Alexandra , Chatzinikolaou Athanasios , Mantzou Aimilia , Stefanaki Charikleia , Papagianni Maria , Fatouros Ioannis , Mastorakos Ge

Objective: To investigate the association of the gonadal axis with pro- and anti- oxidation, in relation to obesity and pubertal status in boys, before and after a stimulatory exercise bout.Design: Cross-sectional human experimental study.Methods: Ninty-two healthy normal-weight and obese pre- and early- pubertal boys, participated in this study. All subjects underwent a baseline blood sampling followed by an aerobic exercise bout ...

hrp0084p2-427 | GH &amp; IGF | ESPE2015

rhGH Replacement Therapy Ameliorates Body Composition Substantially but has No Effect in the Quality of Life in Adolescents with GH deficiency – A Cross-Sectional Study

Stefanaki Charikleia , Paltoglou George , Bacopoulou Flora , Boschiero Dario , Chrousos George P

Background: GH is fundamental in skeletal growth during puberty, however detailed studies of body composition analyses in adolescents with GH deficiency on GH therapy are scarce. Moreover, there are few studies on the psychologic aspects of hrGH therapy in this population.Objective and hypotheses: In this case-control study, we investigated differences in body composition based on bio-impedance measurements between adolescents with idiopathic GH deficien...

hrp0094p2-161 | Diabetes and insulin | ESPE2021

Not every obese child has type 2 Diabetes Mellitus

Koutaki Diamanto , Vourdoumpa Aikaterini , Vasilakis Ioannis-Anargyros , Sertedaki Amalia , Charmandari Evangelia , Paltoglou George ,

Background: Maturity onset Diabetes of the young (MODY) is a rare form of diabetes with specific features that distinguish it from diabetes mellitus type 1 (DM1) or type 2 (Dm2). Research studies suggest that 5% of subjects diagnosed with diabetes before the age of 45 years have MODY, with 80% of them having been incorrectly diagnosed as having DM1 or Dm2. Genetic testing my enable correct diagnosis and treatment, optimize glycemic contro...